Oral Drug Delivery: A Novel Multi-Segment Intestinal Cannulation Approach in Beagle Dogs
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Posters
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August 08,2025
Posters Overview
The discovery and development of oral drug candidates during the preclinical stage require a thorough understanding of how various segments of the gastrointestinal (GI) tract influence absorption. Both small molecule compounds and biologics face significant challenges, such as poor solubility, chemical and enzymatic degradation, variable permeability, first-pass metabolism, efflux mechanisms, immunogenicity, and stability issues. Traditional animal models, including single-segment perfusion in rodents, are limited by their inability to compare across intestinal segments and the non-reusability of animals.
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