Experimental Validation of the Reliability of Dilution Method for Plasma Protein Binding Assay in Human Plasma Using Commercial Compounds

Posters
April 18,2024

Posters Overview

In this study, we validated the accuracy of plasma dilution method for commercial compounds using equilibrium dialysis. Results showed that dilution fold as high as 50 can result in accurate undiluted values for highly bound compounds. Both single dilution method or correction from multiple dilutions can give good prediction of undiluted unbound in plasma for highly bound compounds. For less highly bound compounds, caution is needed when interpreting data from dilution method. Multiple dilutions are recommended in order to generate the most reliable predictions for all the compounds.

84Experimental Validation of the Reliability of Dilution Method for Plasma Protein Binding Assay in Human Plasma Using Commercial Compounds.jpg

Complete the form to view and download this poster.

First name *

* Please check the filled content
Last name *

* Please check the filled content
Email address *

* Please check the filled content
Phone number
Company *

* Please enter a valid e-mail address
Department *

* Please check the filled content
Country *

* Please check the filled content
Position *

* Please check the filled content
City *

* Please check the filled content
Focus area (Service you are interested in)
I want to receive the latest news, insights, and communication from WuXi AppTec DMPK. I understand that I can unsubscribe at any time.

I acknowledge and agree that WuXi AppTec DMPK may transfer my personal information across borders for the purpose of providing products and services through resources worldwide.

By clicking submit below, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy
Submit

Stay Connected

Keep up with the latest news and insights.

Email address*

* Please check the filled content
First name*

* Please check the filled content
Last name*

* Please check the filled content
Company*

* Please check the filled content

By clicking submit, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy

Submit