Evidence-Based Strategies for the Characterization of New Chemical Entity (NCE) In Vitro CYP and Non-CYP Enzyme Reaction Phenotyping at the Development Stage

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April 11,2024

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Successful prediction of the major routes of human clearance of the New Chemical Entity (NCE) is critical for the pharmaceutical industry. Reaction phenotyping has become a standard practice in the process of drug discovery and development. Various in vitro and in vivo methodologies are available for reaction phenotyping at different stages of drug discovery and development.

85Evidence-Based Strategies for the Characterization of New Chemical Entity (NCE) In Vitro CYP and Non-CYP Enzyme Reaction Phenotyping at the Development Stage.jpg

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