Optimization and Assessment of Intrathecal (IT) Administration to Improve Drug Delivery to the CNS in Rats

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July 11,2025

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As a key protective mechanism of the central nervous system (CNS), the blood-brain barrier (BBB) effectively prevents the invasion of neurotoxic substances and blood-borne pathogens through selective permeability. However, this physiological characteristic also significantly limits the bioavailability of therapeutic drugs in the CNS when administered systemically, posing a major challenge in treating neurological diseases. Our team established novel dosing strategies via intrathecal (IT) catheterization in a rat model to enhance drug delivery to the CNS while significantly reducing physiological interference.

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