Desorption Strategies in Peptide Formulation Preparation: Insights from In Vitro Adsorption (Non-Specific Binding) Assessment Experiments

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April 29,2025

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A notable challenge in the formulation process is the observed discrepancy between the actual and nominated concentrations of test articles during preparation. The cause of this discrepancy is complex to identify, and it could stem from non-specific binding or adsorption of peptides onto various surfaces, such as filter membranes, glass containers, and plastic syringes. Other factors, including peptide stability issues, may also contribute to this problem.

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