Development of a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans

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March 21,2024

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Two acrylamide covalent drugs (Abivertinib and Osimertinib) were used as model compounds. An in vitro methodology was designed and utilized for investigating oxidative metabolism, protein binding and GSH conjugations of two acrylamide covalent drugs. This approach integrated metabolite profiling in human liver microsomes (HLM) with and without GSH, along with the exploration of potential covalent binding in human serumalbumin (HSA) with andwithout GSH.

88Development of a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans.jpg

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