Tissue Distribution Using Quantitative Whole Body Autoradiography (QWBA) of [¹⁴c]-Paclitaxel in Tumor Bearing Mice

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May 04,2023

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To determine the tissue distribution of [¹⁴C]-Paclitaxel in tumor bearing mice, we evaluated the tumors derived from MBT2 and MC38 cell lines for colorectal and urinary bladder cancers, respectively, along with the corresponding tissue type for evaluation of differences between these types of tumor cells in female C3H/He and C57BL/6 mice, respectively. Present tumors, vascularity, and corresponding tissues of interest were then analyzed to evaluate the differences in distribution of [¹⁴C]-Paclitaxel-derived radioactivity using QWBA methods.

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Tissue Distribution Using Quantitative Whole Body Autoradiography (QWBA) of [14c]-Paclitaxel in Tumor Bearing Mice

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Tissue Distribution Using Quantitative Whole Body Autoradiography (QWBA) of [¹⁴c]-Paclitaxel in Tumor Bearing Mice