Fast Biomimetic High-Performance Liquid Chromatography Method for Evaluating Human Plasma Protein Binding

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April 29,2025

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This study developed a biomimetic high-performance liquid chromatography (HPLC) method to evaluate human plasma protein binding. This method employs a stationary phase containing human serum albumin (HSA) to mimic the biological environment of drug-protein binding. The chromatographic retention behavior of compounds on the biomimetic stationary phase reveals the affinity of compounds to albumin. This innovative approach overcomes the limitations of conventional techniques, offering a rapid and high-throughput strategy for assessing plasma protein binding of small molecules and peptides, which holds significant implications for efficacy and safety evaluations in drug discovery.

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