The Strategy for UGT Enzyme Phenotyping

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April 29,2025

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In our experimental system, Nilotinib and Regorafenib, two UGT1A1 inhibitors recommended by ICH M12, were found to have off-target effects on UGT1A3 and 1A9, respectively, with off-target inhibition rates exceeding 60%. As a result, we have also verified the specificity of some of the inhibitors for UGT1A1, 1A3, 1A4, 1A9, 2B7, and 2B10 to support further research.

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