Substrate and System-Dependent Activation of CYP2B6

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April 29,2025

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To ensure the activation of CYP2B6, different substrates and assay systems were applied in the study. In general, human liver microsomes (HLM) or recombinant human CYP enzymes were employed as enzyme sources. Bupropion hydroxylation and efavirenz hydroxylation, the marker reactions recommended by the ICH M12, were both used to evaluate the inhibition towards CYP2B6.

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