Application of Lecithin (PL90) and Poloxamer 188 in Permeability and P-GP/BCRP Mediated Drug Interaction Studies in Caco-2 Cells

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April 29,2025

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Highly lipophilic compounds typically exhibit poor aqueous solubility and high non-specific binding. These properties can make conventional in vitro permeability and P-gp/BCRP-mediated drug interaction studies infeasible at intended concentrations. Additionally, high non-specific binding may compromise experimental accuracy, potentially leading to the premature discontinuation of promising candidates.

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