In Vitro Metabolic Stability Evaluation of Peptides

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April 29,2025

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Peptides are rapidly degraded by endogenous proteases in the bloodstream, stomach, intestine, liver, and kidney, hindering their entry into systemic circulation after oral administration. This study evaluated peptide metabolic stability across gastrointestinal, hepatic, renal, and circulatory systems to identify optimal in vitro models for guiding structural optimization.

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