Pharmacokinetic Comparison of Pemetrexed Administered via Lumbar Intrathecal vs. Cisterna Magna Intubation in Sprague-Dawley Rats

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April 29,2025

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In the study of central nervous system (CNS) diseases, commonly employed methods of invasive drug administration in rats include lumbar and/or cisterna magna puncture and intubation.To further evaluate how these delivery routes affect PK profiles, we conducted a study comparing the PK profiles of Pemetrexed (MW: 427 g/mol) administered via lumbar intrathecal intubation versus cisterna magna intubation in Sprague-Dawley (SD) rats.

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