Novel Rat Intrathecal Catheterization Model for Direct Antisense Oligonucleotide (ASO) Drug Delivery to the Central Nervous System
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Posters
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April 29,2025
Posters Overview
The methodology employs a guidewire-assisted catheter implantation through the cauda equina space (L5-L6 intervertebral region), achieving a total incision length of <5 mm to substantially reduce physiological stress caused by surgical procedures. Procedural efficiency is evidenced by an operation time of < 15 minutes per rat, a catheterization success rate > 95%, and a 100% postoperative survival rate. Importantly, this technique circumvents the neurological injury risks associated with traditional lumbar puncture while enabling persistent repeated dosing （more than 4 weeks）.
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