Bioanalytical Strategy for Payloads of Antibody Drug Conjugates (ADCs) with LC-MS Platform

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March 12,2025

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After administration, ADCs can exist in various forms in the body, including intact ADCs, biotransformation products, free payloads, linker-payload conjugates, and related metabolites. Pharmacokinetic studies of ADCs typically require the assessment of total antibodies, conjugated antibodies, free payloads, drug-to-antibody ratios (DAR), conjugated payloads, drug linkers, relevant metabolites, and the immunogenicity of the ADCs. A variety of bioanalytical platforms are needed to understand the actual role of ADCs in disease, including ELISA, LC-HRMS, and LC-MS/MS.

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