Development of a High-throughput and Cost-effective Method for Experimental Polar Surface Area Measurement with Ultra-Performance Convergence Chromatography Tandem Mass Spectrometry

Posters
March 12,2025

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Topological polar surface area (TPSA) is a calculated value defined as the total surface area of polar atoms (usually oxygen, nitrogen, and attached hydrogen) in a molecule. Experimental polar surface area (EPSA) is different from TPSA, which is determined based on the chromatographic retention of the molecule. EPSA is a key physical property to understand the bioavailability of drugs. In this study, a high-throughput and cost-effective ultra-performance convergence chromatography tandem mass spectrometry (UPCC-MS/MS) assay was developed to understand the permeability of drug candidates.

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