Optimization of Sample Pretreatment Methods for LC-MS/MS Determination of Oligonucleotide Drugs in Tissues and Excreta

Posters
March 12,2025

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Liquid-liquid extraction (LLE), due to its low cost and simple operation, is commonly used for oligonucleotide extraction in biomatrices. However, it co-extracts endogenous inorganic salts and acids in tissue and excretion samples, leading to matrix effects and bad peak shape.

This study compares solid-phase extraction (SPE) and LLE, establishing a general, rapid, robust method to solve common LLE issues.

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