Ultimate Exploration of the LLOQ of Exatecan, a Common Antibody Drug Conjugate (ADC) Payload

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March 12,2025

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Exatecan, a derivative of camptothecin, is commonly used as ADC payload for anti-tumor activity. Camptothecin drugs, given their unique lactone ring-containing structure, exhibit different molecular forms (open-ring and closed-ring forms) under acidic and basic conditions, and when detected using liquid chromatography-tandem mass spectrometry (LC-MS/MS), result in different elution time and m/z. Here, we established a simple, accurate, highly sensitive, and robust LC-MS/MS method in preclinical stages to measure camptothecin drugs such as extecan.

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