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An LC-MS/MS Method for Separation and Quantification of Chiral Molecules

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  • March 12,2025

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Stereoisomerism is common in organic chemistry. Some isomers can be identified by mass spectrum, whereas, others like enantiomer or cis-trans-isomer because of the same fragmentation pattern, have to be isolated by liquid chromatogram. In the pharmaceutical industry, about 60% of the drugs currently in use are chiral drugs which most approved chiral drugs are single enantiomers and a small part are racemes. Chiral drugs have attracted much attention from drug regulators and drug developers because of their special differences in pharmacology, toxicology, and pharmacokinetics in vivo.

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