A Robust Method for Detection of Covalent Drugs in Mouse Blood

Posters
March 12,2025

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Covalent drugs have gained widespread attention in drug discovery for the successful treatment of a variety of diseases such as lymphoma, lung, and breast cancer. The covalent binding to proteins such as albumin, acid glycoprotein, globulin, and various lipoproteins presents challenges for the bioanalysis of covalent drugs. Due to the time-dependent covalent binding process in whole blood, the longer the sample is stored, the higher the covalent binding will be. Additionally, the test compound continuously releases from the precipitate to supernatant during protein precipitation pretreatment. Both will affect sample analysis.

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