Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry

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February 22,2024

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Metabolism of GalNAc-siRNA conjugates is mainly catalyzed by exonucleases and endonucleases, resulting in various sizes of shortened oligonucleotides, which could interfere the quantitation of GalNAc-siRNA conjugates. Therefore, bioanalytical scientists have to use a long injection time to separate analyte from metabolites when using LC-MS/MS for quantitation.

95Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry.jpg

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