A Novel Validated LC-MS/MS Approach for Survodutide in Mouse Liver

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March 12,2025

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Survodutide is a potent, acylated peptide that incorporates a C18 fatty acid to extend its half-life. This approach addresses the issue of extracting liver tissue samples by optimizing the homogenate. Furthermore, it resolves the problem of reproducibility of chromatographic peaks by purifying the samples using Protein Precipitation (PPT) and Solid Phase Extraction (SPE).

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