Simultaneous Determination of Metabolites from Seven Key Probe Substrates in CYP Inhibition Assay Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Posters
February 13,2025

Posters Overview

The Cytochrome P450 (CYP) families of enzymes are commonly involved in significant clinical drug-drug interactions (DDIs). A change in the metabolic clearance of these drugs due to changes in the CYP activities can produce severe adverse reactions or a loss of efficacy when two or more drugs are co-administered. To avoid failures in the later stages of drug development or post-marketing, an evaluation of the effects of new molecular entities (NMEs) on CYP activities during the early stages of drug discovery is crucial.

Simultaneous Determination of Metabolites from Seven Key Probe Substrates in CYP Inhibition Assay Using Liquid Chromatography Tandem Mass Spectrometry (LC-MSMS)

Complete the form to view and download this poster.

First name *

* Please check the filled content
Last name *

* Please check the filled content
Email address *

* Please check the filled content
Phone number
Company *

* Please enter a valid e-mail address
Department *

* Please check the filled content
Country *

* Please check the filled content
Position *

* Please check the filled content
City *

* Please check the filled content
Focus area (Service you are interested in)
I want to receive the latest news, insights, and communication from WuXi AppTec DMPK. I understand that I can unsubscribe at any time.

I acknowledge and agree that WuXi AppTec DMPK may transfer my personal information across borders for the purpose of providing products and services through resources worldwide.

By clicking submit below, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy
Submit

Stay Connected

Keep up with the latest news and insights.

Email address*

* Please check the filled content
First name*

* Please check the filled content
Last name*

* Please check the filled content
Company*

* Please check the filled content

By clicking submit, you consent to WuXi AppTec DMPK collecting and processing the information you provide for our internal purposes, in accordance with our privacy policy.

* Please agree to the Privacy Policy

Submit