A Rapid Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for Quantifying the Metabolites of Seven Major Probe Substrates in Human Liver Microsomes

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December 11,2024

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Cytochrome P450 (CYP) family of enzymes are commonly involved in important drug-drug interactions (DDIs). The FDA recommends an in vitro CYP inhibition assay for the 7 major human hepatic CYP isoforms: CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A.

A Rapid Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Quantifying the Metabolites of Seven Major Probe Substrates in Human Liver Microsomes.png

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