The Determinants in Evaluating siRNA Plasma Protein Binding Using Agarose Gel Electrophoretic Mobility Shift Assay (EMSA)

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December 03,2024

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The purpose of the present study was to explore the reasons of the inconsistent conclusions regarding concentration-dependent binding between the reported two methods by performing EMSA PPB in human plasma using a model siRNA drug, Nedosiran, and to identify the limitations within the EMSA method in order to assess its general applicability.

The Determinants in Evaluating siRNA Plasma Protein Binding Using Agarose Gel Electrophoretic Mobility Shift Assay (EMSA)

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