Conferences
20th WRIB | Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy & Vaccines
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April 13-17, 2026
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Dallas, Texas, US
The 20th WRIB (Workshops on Recent Issues in Bioanalysis) will be built on the success of the previous meetings, especially the 19th WRIB where 1200 professionals (in person and remote) representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to discuss current topics of interest in bioanalysis. High Quality, better compliance to regulations and scientific excellence have always been the foundations of WRIB.
20th WRIB continues to feature the unique 3-DAY Full Immersion Main Workshop sequential program including Main Workshop DAY 1, DAY 2 and DAY 3 for those aiming for full immersion in Bioanalysis.
However, for those into certain focus, there is the flexibility to select 2-DAY Main Workshop program by choosing either 2-DAY Ligand-Binding, Cell-Based, and Molecular Assays (DAY 1 & DAY 2) or 2-DAY Mass Spec, Chromatography, and Sample Prep (DAY 2 & DAY 3) based on each attendee's specific field of interest and learning needs.
In addition to the 3-DAY Main Workshop program, there are also 7 Full-Day Specialized Workshops dedicated for advanced training and specific focus spreading throughout the week to further deepen attendees' knowledge with many choices to combine Main Workshop DAYs with these Specialized Workshops to maximize the learning process.
We will be located at booth No. To Be Determined.
Our posters
Other Resources
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Our posters -
Other Resources
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Addressing pH-Dependent Lactone-Carboxylate Interconversion to Resolve Quantitation Bias in the Bioanalysis of Exatecan-Based ADCs
This work identifies and experimentally validates an underappreciated analytical approach in PK bioanalysis, specifically to Exatecan-based ADCs: pH-driven interconversion between lactone and carboxylate forms can create substantial and misleading discrepancies between total antibody (TAb) and conjugated antibody (ADC) measurements. We further demonstrate, with dedicated stability experiments, that a controlled acetic-acid–based acidification procedure can both harmonize analyte speciation and maintain ADC integrity, thereby restoring accurate TAb/cAb quantitation.
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Establishment of a Quantitative Analytical Method for Albumin-Drug Conjugates in Rat Plasma Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Albumin is present in very high concentration in plasma. In the literature, anti-albumin magnetic beads or anti-albumin antibodies were used for enrichment, which was expensive and required a large number of magnetic beads for each sample. This study has developed a high-throughput cold acetone extraction method, which greatly simplified the pretreatment process and shortened the pretreatment time. It is a cost-effective, efficient, and suitable method for the analysis of large-scale biological samples.
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A Novel RT-qPCR Methodology for Quantitative Bioanalysis of Total and Conjugated siRNA in Antibody-Oligonucleotide Conjugates (AOCs)
This study presents a novel RT-qPCR methodology specifically developed for antibody-siRNA conjugate quantification, significantly advancing AOC research and development. The optimized qPCR protocol was rigorously validated for essential performance parameters, including linearity, sensitivity, amplification efficiency, and specificity.
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A High-Sensitivity Stem-Loop RT-qPCR Method for RISC-Loaded siRNA Quantitation
This study aims to establish and validate a highly selective and ultrasensitive bioanalytical method for quantifying RISC-loaded siRNA in target tissues. This approach will enable a more accurate assessment of drug PK/PD profiles and provide a scientific basis for dose optimization of siRNA therapeutics.
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A Novel Derivatization Procedure for the Chemicals with Carboxylic Acid and Its Application in LC-MS/MS Bioanalysis
This work presents a simple, rapid, and broadly applicable derivatization procedure for compounds containing carboxylic acid functional groups. Unlike conventional derivatization approaches that require liquid–liquid extraction, harsh reaction conditions, or specialized solvents, the described method utilizes a straightforward protein precipitation workflow, ambient reaction conditions, commonly used bioanalytical solvents, and significantly reduced reagent consumption. The procedure is readily implementable using standard bioanalytical laboratory equipment without additional training, making it suitable for routine bioanalysis.
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View More -
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Deciphering Nucleoside and Analogs: Mechanisms, Landscape, and Their Phosphates Analysis based on LC-MS/MS
ArticlesFeb 27,2026
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Neonatal Fc Receptor (FcRn): Advances in Autoimmune Therapeutics and Analytical Strategies
ArticlesFeb 10,2026 -
Metabolomics: Definition, Analysis, and Applications
ArticlesFeb 05,2026
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