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Factsheet- Cytochrome P450 Induction: Relative Induction Score (RIS) Analysis

  • Brochures

  • August 01,2025

Brochures Overview

The RIS method predicts in vivo CYP3A4 induction magnitude using in vitro data. It correlates a drug’s induction score (based on Emax, EC50, and unbound Cmax) to clinical AUC changes of midazolam via a calibration curve. Drugs with predicted ≥20% AUC reduction (AUCR ≤0.8) require follow-up (clinical DDI or modeling). Uses qualified hepatocytes and controls (rifampicin/flumazenil).

Factsheet- Cytochrome P450 Induction: Relative Induction Score (RIS) Analysis

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